Journal Of Neuroimmunology, no.143, pp.17-24, 2003 (SCI-Expanded)
A whole genome screen for linkage in Turkish multiple sclerosis
M. Eraksoya,*,1, M. Kurtuncua,b,1, G. Akman-Demira, M. Kılıncc, M. Gedizlioglud, M. Mirzae,
. Anlarf, C. Kutlug, M. Demirkıranh, H.A. I˙drisoglua, A. Compstonb, S. Sawcerb
The Turkish Multiple Sclerosis Genetics Study Group (TMSGSG)2
a Department of Neurology, Istanbul Faculty of Medicine, University of Istanbul, C¸ apa, Istanbul TR-34390, Turkey
b Neurology Unit, Addenbrooke’s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
c Department of Neurology, Faculty of Medicine, University of Baskent, Ankara, Turkey
d Department of Neurology, Buca Social Security Hospital, I˙zmir, Turkey
e Department of Neurology, Gevher Nesibe Faculty of Medicine, University of Erciyes, Kayseri, Turkey
f Department of Neurology, Faculty of Medicine, University of Yu¨zu¨ncu¨ yıl, Van, Turkey
g Department of Neurology, Faculty of Medicine, University of Osmangazi, Eskisehir, Turkey
hDepartment of Neurology, Faculty of Medicine, University of C¸ukurova, Adana, Turkey
Factors exerting recessive effects on susceptibility to complex traits are expected to be over-represented in communities having a higher
frequency of consanguineous marriage. Multiple sclerosis, a typical complex trait, is relatively common in Turkey where cultural factors also
determine a high rate of consanguineous marriage. Previous genetic studies of multiple sclerosis in Turkey have been confined to the search
for associations with candidate genes. In order to exploit the special genetic features of the Turkish population, we performed a whole
genome screen for linkage in 43 Turkish multiplex families employing 392 microsatellite markers. Two genomic regions where maximum
lod score (MLS) values were suggestive of linkage were identified (chromosomes 13q and 18q23) along with a further 14 regions of potential
linkage. Parametric analysis of these data using a recessive model, appropriate for populations with a high frequency of consanguinity,
increased the LOD scores in four regions.
D 2003 Elsevier B.V. All rights reserved.
Keywords: Multiple sclerosis; Turkey; Genome screen; Linkage
0165-5728/$ - see front matter D 2003 Elsevier B.V. All rights reserved.