Akademik Veri Yönetim Sistemi
World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases, Barcelona, İspanya, 4 - 07 Mayıs 2023, ss.253
Objective: Although the concept of sarcopenic obesity (SO) has been around for many years, the first consensus report on its definition was published in 2022. In our study, we aimed to evaluate the relationship of SO, which was determined by the consensus algorithm, with metabolic diseases, i.e., diabetes and dyslipidemia.
Methods: Our study was a retrospective, cross-sectional study, and outpatients aged ≥60 years admitted to the university hospital were included. The diagnosis of sarcopenia was made according to the EWGSOP2 criteria with the presence of low muscle strength+low muscle mass. Threshold values of 27 kg/16 kg were used for hand grip strength in men and women, respectively. Skeletal muscle mass index (SMMI) was determined by adjusting muscle mass for body weight as measured by a bioimpedance analyzer (BIA). Fat percentage measured via BIA was used for the diagnosis of obesity. Turkish population-specific thresholds were used for detection of low SMMI and obesity (37.4%/33.6%, and 27%/41% in males and females, respectively). Cases were grouped into 4 phenotypes according to their body composition: Non-sarcopenia + Non-obesity (non-S+non-O); Sarcopenia+Non-obesity (only S); Non- sarcopenia+Obesity (only O); sarcopenia + obesity (SO). Non-S+Non-O group was taken as reference. The association of body phenotypes with diabetes and dyslipidemia was evaluated in univariate analyses and multivariate analyses including age, gender, and BMI.
Results: There were 672 participants (69.3% women) in the study. Median age was 76 (61-99). The prevalence of diabetes and dyslipidemia were 31.5% and 30.8%, respectively. Among participants, 55.8% had non-S non-O; 1.8% had only S; 39.3% had only O; and 3.1% had SO phenotype. Among the body phenotypes in multivariate analyses, only SO was independently associated with diabetes [OR (95%CI)=4.1 (1.6-10.7), p=0.004] and dyslipidemia [OR (95%CI)=2.7 (1.1-6.8); p=0.04].
Conclusion: In our study, the concept of SO determined by the current consensus algorithm was associated with diabetes and dyslipidemia, while only obesity or only sarcopenia was found to be unrelated. Our study is the first to investigate the relationship between SO defined by consensus diagnostic criteria and metabolic diseases. Additional studies are needed in this regard.