Local Renin-Angiotensin system in normal hematopoietic and multiple myeloma-related progenitor cells.

Uz, Burak; Tatonyan, Suzin; Sayitoglu, Müge; Erbilgin, Yücel; Hatirnaz, Özden; AKSU, SALİH; BÜYÜKAŞIK, YAHYA; SAYINALP, NİLGÜN; GÖKER, HAKAN; ÖZCEBE, OSMAN; Ozbek, Ugur; Haznedaroglu, Ibrahim

doi:10.4274/tjh.2013.0011

Local Renin-Angiotensin system in normal hematopoietic and multiple myeloma-related progenitor cells.

Uz B., Tatonyan S. C., Sayitoglu M., Erbilgin Y., Hatirnaz O., AKSU S., ...Daha Fazla

Turkish journal of haematology : official journal of Turkish Society of Haematology, cilt.31, sa.2, ss.136-42, 2014 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 31 Sayı: 2
Basım Tarihi: 2014
Doi Numarası: 10.4274/tjh.2013.0011
Dergi Adı: Turkish journal of haematology : official journal of Turkish Society of Haematology
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.136-42
İstanbul Üniversitesi Adresli: Evet

Özet

Objective: The prominent functions of the local renin-angiotensin system (RAS) in primitive hematopoiesis further support the hypothesis that local autocrine bone marrow RAS could also be active in neoplastic hematopoiesis. The aim of this study is to examine critical RAS elements in normal CD34+ hematopoietic stem cells and multiple myeloma (MM)-related progenitor cells.