Serum chymase levels in obese individuals: the relationship with inflammation and hypertension

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Topparmak E., TANRIKULU KÜÇÜK S., Oner-Iyidogan Y.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.45, no.3, pp.305-314, 2020 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 45 Issue: 3
• Publication Date: 2020
• Doi Number: 10.1515/tjb-2018-0152
• Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
• Page Numbers: pp.305-314
• Istanbul University Affiliated: Yes

Abstract

Background: Inflammation related hypertension is reported in obesity due to synthesis of angiotensinII (Ang-II) and proinflammatory compounds in obese adipose tissue. Mast cell chymase (MC) also stimulate Ang-II synthesis, and activate transforming growth factor beta-1 (TGF-beta 1) and matrix metalloproteinase-9 (MMP-9). The aim of our study is to evaluate the relation of serum chymase levels, a serine protease enzyme secreted from mast cells, in obese patients with hypertension and cytokines that lead to cell damage.