Neisseria meningitidis with decreased susceptibility to penicillin in Istanbul, Turkey
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, cilt.34, sa.1, ss.11-13, 2002 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 34 Sayı: 1
- Basım Tarihi: 2002
- Doi Numarası: 10.1080/00365540110077344
- Dergi Adı: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.11-13
- İstanbul Üniversitesi Adresli: Evet
Özet
This study was conducted to estimate the rate of decreased susceptibility to penicillin (MIC > 0.06-1 mug/ml) in Neisseria meningitidis isolates in Istanbul, Turkey. A total of 30 isolates collected during a 1-y period from patients with meningitis and from nasopharyngeal carriers were tested for penicillin and cefotaxime susceptibility using the E-test. Two out of 12 (17%) clinical isolates and 11/18 (61%) nasopharyngeal isolates showed decreased susceptibility to penicillin with MICs in the range 0.094-1.0 mug/ml, giving an overall resistance of 43% (n=13). These data show that continued surveillance of trends in antimicrobial susceptibility of N. meningitidis is important for detecting the emergence of N. meningitidis strains with MICs > 1 mug/ml which may pose serious therapeutic problems.