Neisseria meningitidis with decreased susceptibility to penicillin in Istanbul, Turkey

PUNAR M., ERAKSOY H., CAGATAY A. , OZSUT H. , Kaygusuz A. , CALANGU S., ...More

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, vol.34, no.1, pp.11-13, 2002 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 1
  • Publication Date: 2002
  • Doi Number: 10.1080/00365540110077344
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.11-13


This study was conducted to estimate the rate of decreased susceptibility to penicillin (MIC > 0.06-1 mug/ml) in Neisseria meningitidis isolates in Istanbul, Turkey. A total of 30 isolates collected during a 1-y period from patients with meningitis and from nasopharyngeal carriers were tested for penicillin and cefotaxime susceptibility using the E-test. Two out of 12 (17%) clinical isolates and 11/18 (61%) nasopharyngeal isolates showed decreased susceptibility to penicillin with MICs in the range 0.094-1.0 mug/ml, giving an overall resistance of 43% (n=13). These data show that continued surveillance of trends in antimicrobial susceptibility of N. meningitidis is important for detecting the emergence of N. meningitidis strains with MICs > 1 mug/ml which may pose serious therapeutic problems.