Aim: During reperfusion of myocardial ischemia, damage can also be seen in the kidneys. Although many studies have been conducted on the underlying mechanisms, the basic mechanism of this interaction is still unknown. We think that this is oxidative/nitrosative damage caused by hypoperfusion. Nebivolol is a beta-blocker with nitric oxide (NO)-mediated effects. In this study, we aimed to investigate the NO-mediated effect of nebivolol on acute renal injury (ARI) developed after myocardial ischemia-reperfusion (IR).