Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates

Szenker-Ravi, Emmanuelle; Ott, Tim; Khatoo, Muznah; de Bellaing, Anne; Goh, Wei; Chong, Yan; Beckers, Anja; Kannesan, Darshini; Louvel, Guillaume; Anujan, Priyanka; Ravi, Vydianathan; Bonnard, Carine; Moutton, Sebastien; Schoen, Patric; Fradin, Melanie; Colin, Estelle; Megarbane, Andre; Daou, Linda; Chehab, Ghassan; Di Filippo, Sylvie; Rooryck, Caroline; Deleuze, Jean-Francois; Boland, Anne; Arribard, Nicolas; Eker, Rukiye; Tohari, Sumanty; Ng, Alvin; Rio, Marlene; Lim, Chun; Eisenhaber, Birgit; Eisenhaber, Frank; Venkatesh, Byrappa; Amiel, Jeanne; Crollius, Hugues; Gordon, Christopher; Gossler, Achim; Roy, Sudipto; Attie-Bitach, Tania; Blum, Martin; Bouvagnet, Patrice; Reversade, Bruno

doi:10.1038/s41588-021-00970-4

Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates

Szenker-Ravi E., Ott T., Khatoo M., de Bellaing A. M., Goh W. X., Chong Y. L., ...More

NATURE GENETICS, vol.54, no.1, pp.62-72, 2022 (SCI-Expanded)

Publication Type: Article / Article
Volume: 54 Issue: 1
Publication Date: 2022
Doi Number: 10.1038/s41588-021-00970-4
Journal Name: NATURE GENETICS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database, DIALNET
Page Numbers: pp.62-72
Istanbul University Affiliated: No

Abstract

Phylogenomic and genetic analyses identify an ancestral module of genes expressed specifically in ciliated left-right organizer tissue and required for left-right axis specification in humans and certain vertebrates.