The effect of methotrexate monotherapy on treatment-resistant idiopathic granulomatous mastitis patients

PAPİLA KUNDAKTEPE B., VELİDEDEOĞLU M., METE B.

SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND, cilt.20, sa.3, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 3
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/j.surge.2021.03.001
  • Dergi Adı: SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE
  • Anahtar Kelimeler: Idiopathic granulomatous mastitis, Methotrexate, Monotherapy, LOBULAR MASTITIS, ERYTHEMA-NODOSUM, DIAGNOSIS, DISEASE, ASSOCIATION, MANAGEMENT, THERAPY
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Background: Idiopathic granulomatous mastitis (IGM) is a disease of unknown etiology, involving a chronic inflammatory process, characterized by noncaseating granuloma formation. IGM can mimic a tumor clinically and radiologically. Since we are a tertiary referral center, most of our patients (n = 56, 87.5%) are secondary admissions who have previously had antibiotics and steroid treatments; therefore, we accept these patients as resistant cases. Here, we aim to present our single-center series of 64 patients with resistant IGM who underwent methotrexate monotherapy. To the best of our knowledge, our study includes the highest number of patients described in the literature with IGM who have undergone this treatment.