The effect of methotrexate monotherapy on treatment-resistant idiopathic granulomatous mastitis patients


PAPİLA KUNDAKTEPE B., VELİDEDEOĞLU M., METE B.

SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND, vol.20, no.3, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.1016/j.surge.2021.03.001
  • Journal Name: SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE
  • Keywords: Idiopathic granulomatous mastitis, Methotrexate, Monotherapy, LOBULAR MASTITIS, ERYTHEMA-NODOSUM, DIAGNOSIS, DISEASE, ASSOCIATION, MANAGEMENT, THERAPY
  • Istanbul University Affiliated: No

Abstract

Background: Idiopathic granulomatous mastitis (IGM) is a disease of unknown etiology, involving a chronic inflammatory process, characterized by noncaseating granuloma formation. IGM can mimic a tumor clinically and radiologically. Since we are a tertiary referral center, most of our patients (n = 56, 87.5%) are secondary admissions who have previously had antibiotics and steroid treatments; therefore, we accept these patients as resistant cases. Here, we aim to present our single-center series of 64 patients with resistant IGM who underwent methotrexate monotherapy. To the best of our knowledge, our study includes the highest number of patients described in the literature with IGM who have undergone this treatment.