Cell proliferation rate and telomerase activity in the differential diagnosis between benign and malignant mesothelial proliferations
PATHOLOGY, vol.38, no.1, pp.10-15, 2006 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 38 Issue: 1
- Publication Date: 2006
- Doi Number: 10.1080/00313020500456017
- Journal Name: PATHOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.10-15
- Istanbul University Affiliated: Yes
Abstract
Aims: The differential diagnosis of malignant mesothelioma ( MM) from benign mesothelial lesions ( BML) based on histopathological criteria is sometimes not satisfying and causes diagnostic problems for histopathologists. We aimed to investigate whether the immunohistochemically determined cell proliferation rate and telomerase activity, using Ki-67 and human telomerase reverse transcriptase ( hTERT) immunohistochemistry, respectively, are useful in the differential diagnosis of MM from BML.