Cell proliferation rate and telomerase activity in the differential diagnosis between benign and malignant mesothelial proliferations

Cakir C., Gulluoglu M., Yilmazbayhan D.

PATHOLOGY, cilt.38, sa.1, ss.10-15, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 1
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1080/00313020500456017
  • Dergi Adı: PATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.10-15
  • İstanbul Üniversitesi Adresli: Evet

Özet

Aims: The differential diagnosis of malignant mesothelioma ( MM) from benign mesothelial lesions ( BML) based on histopathological criteria is sometimes not satisfying and causes diagnostic problems for histopathologists. We aimed to investigate whether the immunohistochemically determined cell proliferation rate and telomerase activity, using Ki-67 and human telomerase reverse transcriptase ( hTERT) immunohistochemistry, respectively, are useful in the differential diagnosis of MM from BML.