Comparison of microvasculature between neovascular, non-neovascular chronic central serous chorioretinopathy cases and asymptomatic fellow eyes using swept-source optical coherence tomography angiography

Soylu C., Cebeci Z.

International Ophthalmology, cilt.45, sa.1, 2025 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 1
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1007/s10792-025-03673-5
  • Dergi Adı: International Ophthalmology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE
  • Anahtar Kelimeler: Choriocapillaris vessel density, Choroidal neovascularization, Chronic central serous chorioretinopathy, Deep capillary plexus vessel density, Superficial capillary plexus vessel density, Swept-source optical coherence tomography angiography
  • İstanbul Üniversitesi Adresli: Evet

Özet

Purpose: To compare microvasculature changes between neovascular, non-neovascular chronic central serous chorioretinopathy cases (cCSCR) and asymptomatic fellow eyes using swept-source optical coherence tomography angiography (SS-OCTA). Methods: Medical records of 70 treatment-naïve patients with chronic central serous chorioretinopathy (cCSCR) who had undergone spectral-domain optical coherence tomography (SD-OCT) and SS-OCTA were reviewed. Among 132 eyes, 81 were diagnosed with cCSCR, 51 eyes were included as asymptomatic fellow eyes. Eyes diagnosed with cCSCR were divided into two groups based on the presence of choroidal neovascularization (CNV) in outer retinal slab on OCTA. There were 3 groups: CNV (+), CNV (−) cCSCR and asymptomatic fellow eyes. Vessel density (VD) in macular region was measured in automatically segmented superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris (CC) slabs and compared between these 3 groups. Results: Mean age of cCSCR patients was 55,83 ± 8,55 years. In 81 eyes diagnosed with cCSCR, 27 eyes were CNV (+) and 54 eyes were CNV (−) on OCTA. Patients with CNV (+) on OCTA were significantly older than CNV (−) patients (p < 0.05). CNV (+) patients’ best- corrected visual acuity (BCVA) was significantly lower than CNV (−) patients (p < 0.01). Subfoveal choroidal thickness (SFCT) of CNV (+) eyes was significantly lower than CNV (−) eyes (p < 0.01). Foveal SCP VD and CC VD of CNV (+) and CNV (−) eyes were significantly lower than asymptomatic fellow eyes (p < 0.05). Foveal DCP VD of CNV (+) and CNV (−) eyes was significantly higher than asymptomatic fellow eyes (p < 0.05). Foveal, parafoveal superior and temporal CC VD of CNV (+) eyes was significantly lower than CNV (−) eyes (p < 0.05). Conclusions: Retinal and choroidal microcirculation difference between neovascular and non-neovascular cCSCR eyes may be an indicator of ischemia, therefore a contributing factor in neovascularization development.