Dimethyl sulfoxide increases the antitumor cytotoxicities of 5-fluorouracil and adriamycin on FMA-3 cell line cultures in tumor colony-forming assays

Bilir A., Ozmen V., Cabioglu N., Muslumanoglu M., Bozfakioglu Y., Igci A., ...More

10th International Congress on Senology - Breast Diseases of the Senologic-International-Society, OPORTO, Portugal, 31 May - 04 June 1998, pp.605-611 identifier

  • Publication Type: Conference Paper / Full Text
  • Volume:
  • City: OPORTO
  • Country: Portugal
  • Page Numbers: pp.605-611
  • Istanbul University Affiliated: Yes


Background: Previous studies demonstrated that combinations of dimethyl sulfoxide (DMSO) with several antineoplastic agents produced in vitro synergistic cytotoxicity against some human tumors. The purpose of this study was to determine if 2% DMSO also enhances the antitumor activity of various chemotherapeutic agents against FMA-3 mouse mammary tumor cell lines performing tumor colony-forming assays.