Akademik Veri Yönetim Sistemi
Nuclear Medicine Communications, cilt.46, sa.9, ss.895-904, 2025 (SCI-Expanded)
Objective To assess the diagnostic performance of Prostate Imaging for Recurrence Reporting (PI-RR) system using 68Ga prostate-specific membrane antigen (PSMA)-11 (HBED-CC) PET/MRI in prostate cancer (PCa) patients with biochemical recurrence (BCR). Methods PET/MRI data of 31 PCa patients [17 with radical prostatectomy (RP) and 14 with radiotherapy (RT)] with BCR were retrospectively analyzed. All patients underwent PSMA PET/MRI and multiparametric prostate MRI (mpMRI). Images were evaluated using PI-RR system for mpMRI and the European Association of Nuclear Medicine standardized reporting guidelines (E-PSMA) for PET, with PI-RR and E-PSMA scores dichotomized as ≤2 negative and ≥3 positive for recurrence. Diagnostic performances were assessed using expert-based ground truth establishment. Results Sensitivity, specificity, and accuracy were 64.7%, 85.7%, and 74.2%, respectively, for PET and 70.6%, 100%, and 83.9%, respectively, for PI-RR. While PI-RR did not reveal any false positive lesions, five patients with false negative PI-RR results were also negative with PET. In patients with RP, sensitivity, specificity, and accuracy were 44.4%, 100%, and 70.6%, respectively, for PET and 55.6%, 100%, and 76.5%, respectively, for PI-RR. For patients with RT, these values were 87.5%, 66.7%, and 78.6%, respectively, for PET and 87.5%, 100%, and 92.9%, respectively, for PI-RR. There was no significant performance difference between PET or PI-RR in all patients (P = 0.564), patients with RP (P = 0.317), or RT (P = 0.157). Conclusion 68Ga PSMA PET evaluation with E-PSMA and mpMRI interpretation with PI-RR have similar diagnostic performance for detection of local recurrence after RP or RT in PCa.