Variations in systemic biomarkers of oxidative/nitrosative stress and DNA damage before and during the consequent two cycles of chemotherapy in breast cancer patients

Atukeren P., Yavuz B., Soydinc H. O., Purisa S., Camlica H., Gumustas M. K., ...More

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, vol.48, no.10, pp.1487-1495, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 10
  • Publication Date: 2010
  • Doi Number: 10.1515/cclm.2010.249
  • Journal Name: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1487-1495
  • Keywords: 8-hydroxydeoxyguanosine, breast cancer, chemotherapy, nitrosative stress, oxidative stress, CELL LUNG-CANCER, LIPID-PEROXIDATION, ANTIOXIDANT STATUS, OXIDATIVE STRESS, NITRIC-OXIDE, BLOOD, TUMOR, ANTHRACYCLINE, ADRIAMYCIN, CAPACITY
  • Istanbul University Affiliated: Yes

Abstract

Background: Previous studies have suggested the importance of redox regulation in carcinogenesis. The aim of this study was to evaluate the prognostic role of altered redox homeostasis and oxidative DNA damage in patients with breast carcinoma before and during two cycles of chemotherapy.