Cupric Oxide Nanoparticles Induce Cellular Toxicity in Liver and Intestine Cell Lines

Abudayyak M. F., Guzel E., ÖZHAN G.

ADVANCED PHARMACEUTICAL BULLETIN, cilt.10, sa.2, ss.213-220, 2020 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.34172/apb.2020.025
  • Dergi Adı: ADVANCED PHARMACEUTICAL BULLETIN
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.213-220
  • Anahtar Kelimeler: Copper oxide, Nanoparticle, DNA damage, Cytotoxicity, Oxidative stress, Apoptosis, CUO NANOPARTICLES, OXIDATIVE STRESS, IN-VITRO, PERMEABILITY TRANSITION, COPPER, CYTOTOXICITY, GENOTOXICITY, KERATINOCYTES, NANOTOXICITY, HEPATOCYTES
  • İstanbul Üniversitesi Adresli: Evet

Özet

Purpose: The wide application of cupric oxide nanoparticles (copper (II) oxide, CuO-NPs) in various fields has increased exposure to the kind of active nanomaterials, which can cause negative effects on human and environment health. Although CuO-NPs were reported to be harmful to human, there is still a lack information related to their toxic potentials. In the present study, the toxic potentials of CuO-NPs were evaluated in the liver (HepG2 hepatocarcinoma) and intestine (Caco-2 colorectal adenocarcinoma) cells.