Cupric Oxide Nanoparticles Induce Cellular Toxicity in Liver and Intestine Cell Lines

Abudayyak M. F., Guzel E., ÖZHAN G.

ADVANCED PHARMACEUTICAL BULLETIN, vol.10, no.2, pp.213-220, 2020 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.34172/apb.2020.025
  • Journal Name: ADVANCED PHARMACEUTICAL BULLETIN
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.213-220
  • Keywords: Copper oxide, Nanoparticle, DNA damage, Cytotoxicity, Oxidative stress, Apoptosis, CUO NANOPARTICLES, OXIDATIVE STRESS, IN-VITRO, PERMEABILITY TRANSITION, COPPER, CYTOTOXICITY, GENOTOXICITY, KERATINOCYTES, NANOTOXICITY, HEPATOCYTES
  • Istanbul University Affiliated: Yes

Abstract

Purpose: The wide application of cupric oxide nanoparticles (copper (II) oxide, CuO-NPs) in various fields has increased exposure to the kind of active nanomaterials, which can cause negative effects on human and environment health. Although CuO-NPs were reported to be harmful to human, there is still a lack information related to their toxic potentials. In the present study, the toxic potentials of CuO-NPs were evaluated in the liver (HepG2 hepatocarcinoma) and intestine (Caco-2 colorectal adenocarcinoma) cells.