Copy For Citation
Abudayyak M. F., Guzel E., ÖZHAN G.
ADVANCED PHARMACEUTICAL BULLETIN, vol.10, no.2, pp.213-220, 2020 (ESCI)
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Publication Type:
Article / Article
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Volume:
10
Issue:
2
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Publication Date:
2020
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Doi Number:
10.34172/apb.2020.025
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Journal Name:
ADVANCED PHARMACEUTICAL BULLETIN
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Journal Indexes:
Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals
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Page Numbers:
pp.213-220
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Keywords:
Copper oxide, Nanoparticle, DNA damage, Cytotoxicity, Oxidative stress, Apoptosis, CUO NANOPARTICLES, OXIDATIVE STRESS, IN-VITRO, PERMEABILITY TRANSITION, COPPER, CYTOTOXICITY, GENOTOXICITY, KERATINOCYTES, NANOTOXICITY, HEPATOCYTES
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Istanbul University Affiliated:
Yes
Abstract
Purpose: The wide application of cupric oxide nanoparticles (copper (II) oxide, CuO-NPs) in various fields has increased exposure to the kind of active nanomaterials, which can cause negative effects on human and environment health. Although CuO-NPs were reported to be harmful to human, there is still a lack information related to their toxic potentials. In the present study, the toxic potentials of CuO-NPs were evaluated in the liver (HepG2 hepatocarcinoma) and intestine (Caco-2 colorectal adenocarcinoma) cells.