IS PENTRAXIN-3 STRONGER THAN C-REACTIVE PROTEIN TO DETERMINE INFLAMMATION IN PERITONEAL DIALYSIS PATIENTS?


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Gursu M., Ozturk S. , Aydin Z., Karadag S., Doventas Y., Koldas M., ...More

EUROPEAN JOURNAL OF INFLAMMATION, vol.10, no.3, pp.289-295, 2012 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.1177/1721727x1201000305
  • Title of Journal : EUROPEAN JOURNAL OF INFLAMMATION
  • Page Numbers: pp.289-295

Abstract

Pentraxin-3 (PTX-3) is the prototype of long pentraxins and is produced by many tissues and organs including vascular endothelial cells in response to pro-inflammatory signals. It is thought to be an independent indicator of disease activity. We analyzed the correlation of PTX-3 with other markers of inflammation in peritoneal dialysis (PD) patients. Non-diabetic patients on chronic PD program who meet the dialysis adequacy criteria and who had no active infectious/inflammatory disease were included. Demographic and clinical parameters were recorded as well as hsCRP, fibrinogen, interleukin-6 (IL-6) and PTX-3 levels; and the correlation between them were studied. Twenty-five patients (mean age: 45.7 +/- 12.5 years; female/male ratio: 16/9) were included. Mean PTX-3 level was 2.16 +/- 2.76ng/ml. PTX-3 was found to be correlated positively with only IL-6 among inflammatory markers (r=0.827; p<0.001) but not with hsCRP. With linear regression model, IL-6 was the only independent determinant of PTX-3 levels. PTX-3 may be a more valuable marker of inflammation than CRP in patients on PD.