Evaluation of T lymphocyte subgroups in patients with chronic lymphocytic leukemia Kronik lenfositik lösemili hastalarda T lenfosit alt gruplarının değerlendirilmesi
Turkish Journal of Immunology, cilt.8, sa.1, ss.6-12, 2020 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 8 Sayı: 1
- Basım Tarihi: 2020
- Doi Numarası: 10.25002/tji.2020.1240
- Dergi Adı: Turkish Journal of Immunology
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.6-12
- Anahtar Kelimeler: Chronic Lymphocytic Leukemia, CLL, Follicular T cells
- İstanbul Üniversitesi Adresli: Evet
Özet
Introduction: Chronic lymphocytic leukemia (CLL) that arises by malignant transformation of mature B cell is the most common leukemia in elderly. CLL is characterized by accumulation of CD5+CD19+ cells in the peripheral blood and lymphoid organs. While CD8+ T lymphocytes response intracellular pathogen and tumor, CD4+ T lymphocytes regulate immune response. T follicular (Tfol) cells stimulate affinity maturation and class-switch recombination in B lymphocytes due to cytokine and surface molecules. In this study, we aimed to investigate CD4+T, CD8+T and CD3+CD4+CXCR5+ follicular T (Tfol) cells in the peripheral blood of the CLL patients compared to healthy controls. Materials and Methods: Peripheral blood samples were collected from 37 patients with CLL and 16 healthy subjects. CD4+ T, CD8+ T and Tfol cells in peripheral blood samples were analyzed by flow cytometry. Results: CD4+ T, CD8+ T and Tfol cells were decreased in all lymphocyte population, CD4+T cells are decreased, and CD8+ T and Tfol cells are increased but in T cell population. There was no differences T cell subgroups and clinical outcome. Conclusions: Although the high CD8+ T lymphocyte and Tfol cell ratios observed in patients may not be a prognostic marker for the clinical course of the disease, the increased Tfol cell ratio as a result of the disease may be the source of the cytokines required for the survival and proliferation of leukemic B cells and the induction of enzymes that were though to be associated with chromosomal deletions in these cells.