Association of cholesteryl ester transfer protein-629C > A polymorphism with high-density lipoprotein cholesterol levels in coronary artery disease patients

Tanrikulu S., Ademoglu E., Gurdol F., Mutlu-Turkoglu U., Bilge A. K., Nisanci Y.

CELL BIOCHEMISTRY AND FUNCTION, cilt.27, sa.7, ss.452-457, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 7
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1002/cbf.1593
  • Dergi Adı: CELL BIOCHEMISTRY AND FUNCTION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.452-457
  • İstanbul Üniversitesi Adresli: Evet

Özet

In Turkish population, plasma HDL-C levels were found to be lower than in any other country and it is suggested that this is associated with genetic origin. The cholesteryl ester transfer protein (CETP) -629C > A polymorphism is associated with lower plasma CETP concentration, with increased HDL-C level. In the present study, the frequency of -629C > A polymorphism in patients with coronary artery disease (CAD) was investigated and the effect of genotype on HDL-C was evaluated in a Turkish population. For this aim CETP -629C > A polymorphism was studied in angiographically documented CAD patients and healthy controls.