Association of cholesteryl ester transfer protein-629C > A polymorphism with high-density lipoprotein cholesterol levels in coronary artery disease patients

Tanrikulu S., Ademoglu E., Gurdol F., Mutlu-Turkoglu U., Bilge A. K., Nisanci Y.

CELL BIOCHEMISTRY AND FUNCTION, vol.27, no.7, pp.452-457, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 7
  • Publication Date: 2009
  • Doi Number: 10.1002/cbf.1593
  • Journal Name: CELL BIOCHEMISTRY AND FUNCTION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.452-457
  • Istanbul University Affiliated: Yes

Abstract

In Turkish population, plasma HDL-C levels were found to be lower than in any other country and it is suggested that this is associated with genetic origin. The cholesteryl ester transfer protein (CETP) -629C > A polymorphism is associated with lower plasma CETP concentration, with increased HDL-C level. In the present study, the frequency of -629C > A polymorphism in patients with coronary artery disease (CAD) was investigated and the effect of genotype on HDL-C was evaluated in a Turkish population. For this aim CETP -629C > A polymorphism was studied in angiographically documented CAD patients and healthy controls.