Varicella is a primary disease of varicella zoster virus (VZV), which is among the human herpes viruses. Chickenpox is a disease that can be easily transmitted by airway, droplet and direct contact to the infected person. Skin lesions after varicella infection are the most common complication of staphylococcal or streptococcal secondary infections. Occasionally, necrotizing fasciitis and severe skin defects develop afterwards. Pneumonia, carditis, hepatitis, glomerulonephritis, encephalitis are among the criminal commissions. Streptococcal toxic shock syndrome (STSR) is a severe clinical picture of one of the group of streptococcal invasive infections, with sudden and rapid onset of shock and organ failure, with a mortality rate of 30-50%. In this study, we present a case of STSR which is a rare and life-threatening clinical entity that develops rarely after varicella infection.