Serum NGF levels may be associated with intrauterine antiepileptic exposure-related developmental problems

Karayagmurlu A., DURSUN O. B., ESİN İ. S., Coskun M.

EPILEPSY & BEHAVIOR, cilt.97, ss.60-66, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 97
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.yebeh.2019.05.013
  • Dergi Adı: EPILEPSY & BEHAVIOR
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.60-66
  • Anahtar Kelimeler: Epilepsy, Antiepileptic drugs, Neurodevelopmental outcomes, Nerve growth factor, PRENATAL EXPOSURE, CHILDREN, EPILEPSY, DRUGS, ACID, NEUROTROPHINS, DISORDERS, DENVER, FOLATE, WOMEN
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: It has been shown that maternal epilepsy and antiepileptic drug use during pregnancy have adverse developmental outcomes in children. The aim of this study was to investigate the developmental outcomes of maternal epilepsy and prenatal antiepileptic exposure. We also looked for the associations between serum levels of glial cell-derived neurotrophic factor (GDNF) and nerve growth factor (NGF) and developmental outcomes.