Serum NGF levels may be associated with intrauterine antiepileptic exposure-related developmental problems

Karayagmurlu A., DURSUN O. B., ESİN İ. S., Coskun M.

EPILEPSY & BEHAVIOR, vol.97, pp.60-66, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 97
  • Publication Date: 2019
  • Doi Number: 10.1016/j.yebeh.2019.05.013
  • Journal Name: EPILEPSY & BEHAVIOR
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.60-66
  • Keywords: Epilepsy, Antiepileptic drugs, Neurodevelopmental outcomes, Nerve growth factor, PRENATAL EXPOSURE, CHILDREN, EPILEPSY, DRUGS, ACID, NEUROTROPHINS, DISORDERS, DENVER, FOLATE, WOMEN
  • Istanbul University Affiliated: Yes

Abstract

Objective: It has been shown that maternal epilepsy and antiepileptic drug use during pregnancy have adverse developmental outcomes in children. The aim of this study was to investigate the developmental outcomes of maternal epilepsy and prenatal antiepileptic exposure. We also looked for the associations between serum levels of glial cell-derived neurotrophic factor (GDNF) and nerve growth factor (NGF) and developmental outcomes.