Preclinical Evaluation of F-18-ML-10 to Determine Timing of Apoptotic Response to Chemotherapy in Solid Tumors

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Demirci E., Ahmed R., Ocak M., Latoche J., Radelet A., DeBlasio N., ...More

MOLECULAR IMAGING, vol.16, 2017 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 16
• Publication Date: 2017
• Doi Number: 10.1177/1536012116685941
• Journal Name: MOLECULAR IMAGING
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Keywords: molecular imaging, apoptosis, early response, F-18-ML-10, PET, POSITRON-EMISSION-TOMOGRAPHY, FLOW-CYTOMETRIC DETECTION, ANNEXIN-V, PHOSPHATIDYLSERINE EXPRESSION, THERAPY RESPONSE, CELL-DEATH, PET, CANCER, TRACER, CARCINOMA
• Istanbul University Affiliated: Yes

Abstract

Purpose: We investigated 2-(5-fluoro-pentyl)-2-methyl-malonic acid (F-18-ML-10) positron emission tomography (PET) imaging of apoptosis posttherapy to determine optimal timing for predicting chemotherapy response in a mouse head/neck xenograft cancer model.