Association between non-coding polymorphisms of HOPX gene and syncope in hypertrophic cardiomyopathy

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Gulec C., Abaci N., Bayrak F., BAYRAK E. K., KAHVECI G., Guven C., ...More

ANATOLIAN JOURNAL OF CARDIOLOGY, vol.14, no.7, pp.617-624, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 7
  • Publication Date: 2014
  • Doi Number: 10.5152/akd.2014.4972
  • Journal Name: ANATOLIAN JOURNAL OF CARDIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.617-624
  • Keywords: HOPX, hypertrophic cardiomyopathy, syncope, modifier gene, polymorphism, SERUM RESPONSE FACTOR, SQUAMOUS-CELL CARCINOMA, LEFT-VENTRICULAR HYPERTROPHY, HOMEODOMAIN PROTEIN, CARDIAC-HYPERTROPHY, HEART-FAILURE, SUDDEN-DEATH, LUNG-CANCER, EXPRESSION, MUTATIONS
  • Istanbul University Affiliated: Yes

Abstract

Objective: Homeodomain Only Protein X (HOPX) is an unusual homeodomain protein which regulates Serum Response Factor (SRF) dependent gene expression. Due to the regulatory role of HOPX on SRF activity and the regulatory role of SRF on cardiac hypertrophy, we aimed to investigate the relationship between HOPX gene variations and hypertrophic cardiomyopathy (HCM).