NUCLEOLAR ORGANIZER REGIONS IN PITUITARY-GLAND ADENOMAS


BAYINDIR C., DOGAN O., UNAL F., DERVISOGLU S.

CYTOPATHOLOGY, cilt.3, ss.223-229, 1992 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Nucleolar organizer regions are DNA segments concerned with the synthesis of ribosomal RNA (rRNA). Some specific proteins related to NORs can be demonstrated by a silver technique and are then referred to as Ag-NORs. The mean number of Ag-NORs per cell has been used as a marker of cell proliferation in recent years and there is some evidence to suggest that Ag-NOR counts can be used to differentiate between normal and neoplastic cells.