Successful Management of Chronic Refractory Immune Thrombocytopenia with Laparoscopic Splenectomy in a Patient with Acute Promyelocytic Leukemia

Eskazan A. E., Salihoglu A., Gulturk E., Aydin S. O., Tuzuner N., Aydin Y.

INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION, vol.29, no.3, pp.173-177, 2013 (SCI-Expanded) identifier identifier identifier


Acute promyelocytic leukemia (APL) is a particular type of acute myeloid leukemia with characteristic biological and clinical features, the frequent association at diagnosis of a severe hemorrhagic diathesis. Immune thrombocytopenia (ITP) is a common autoimmune disease characterized by low platelet counts and an increased risk of bleeding. Here we present a patient with the diagnosis of APL who achieved and maintained a remission with an induction consisting of idarubicin and ATRA, and then developed corticosteroid refractory ITP which is successfully treated with laparoscopic splenectomy.