Successful Management of Chronic Refractory Immune Thrombocytopenia with Laparoscopic Splenectomy in a Patient with Acute Promyelocytic Leukemia


Eskazan A. E. , Salihoglu A., Gulturk E., Aydin S. O. , Tuzuner N., Aydin Y.

INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION, vol.29, no.3, pp.173-177, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.1007/s12288-012-0173-8
  • Title of Journal : INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
  • Page Numbers: pp.173-177

Abstract

Acute promyelocytic leukemia (APL) is a particular type of acute myeloid leukemia with characteristic biological and clinical features, the frequent association at diagnosis of a severe hemorrhagic diathesis. Immune thrombocytopenia (ITP) is a common autoimmune disease characterized by low platelet counts and an increased risk of bleeding. Here we present a patient with the diagnosis of APL who achieved and maintained a remission with an induction consisting of idarubicin and ATRA, and then developed corticosteroid refractory ITP which is successfully treated with laparoscopic splenectomy.