Effects of insulin-like growth factor-I and platelet-rich plasma on sciatic nerve crush injury in a rat model

Emel E., Ergun S. S. , KOTAN D., Gursoy E. B. , Parman Y., Zengin A., ...More

JOURNAL OF NEUROSURGERY, vol.114, no.2, pp.522-528, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 114 Issue: 2
  • Publication Date: 2011
  • Doi Number: 10.3171/2010.9.jns091928
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.522-528
  • Istanbul University Affiliated: Yes


Object. Local administration of insulin-like growth factor-I (IGF-I) has been shown to increase the rate of axon regeneration in crush-injured and freeze-injured rat sciatic nerves. Local administration of platelet-rich plasma (PRP) has been also shown to have a measurable effect on facial nerve regeneration after transection in a rat model. The objective of the study was to compare the effects of locally administered IGF-I and PRP on the parameters of the Sciatic Function Index (SFI), sensory function (SF), axon count, and myelin thickness/axon diameter ratio (G-ratio) in a rat model of crush-injured sciatic nerves.