A review on the dosimetrical and radiobiological prediction of radiation-induced hypothyroidism in radiation therapy of head-and-neck cancer, breast cancer, and Hodgkin's lymphoma survivors


Mohammad Namdar A., Mohammadzadeh M., Okutan M. , Mesbahi A.

POLISH JOURNAL OF MEDICAL PHYSICS AND ENGINEERING, vol.24, no.4, pp.137-148, 2018 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Review
  • Volume: 24 Issue: 4
  • Publication Date: 2018
  • Doi Number: 10.2478/pjmpe-2018-0020
  • Title of Journal : POLISH JOURNAL OF MEDICAL PHYSICS AND ENGINEERING
  • Page Numbers: pp.137-148

Abstract

A review on the radiobiological modeling of radiation-induced hypothyroidism after radiation therapy of head-and-neck cancers, breast cancer, and Hodgkin's lymphoma is presented. The current review is based on data relating to dose-volume constrains and normal tissue complication probability (NTCP) as a function of either radiobiological or (pre)treatment-clinical parameters. Also, these data were explored in order to provide more helpful criteria for radiobiological optimization of treatment plans involving thyroid gland as a critical normal organ.