Combined effect of parathyroid hormone and strontium ranelate on bone healing in ovariectomized rats

GÖKER F., Ersanli S., Arisan V., Cevher E., Guzel E. E., Issever H., ...Daha Fazla

ORAL DISEASES, cilt.24, sa.7, ss.1255-1269, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 7
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1111/odi.12895
  • Dergi Adı: ORAL DISEASES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1255-1269
  • Anahtar Kelimeler: bone healing, chitosan, osteoporosis, ovariectomized rat, parathyroid hormone, strontium ranelate, CHITOSAN NANOPARTICLES, HYDROXYAPATITE COATINGS, POSTMENOPAUSAL WOMEN, SYNTHETIC MATRIX, MINERAL DENSITY, TERIPARATIDE, REGENERATION, ALENDRONATE, OSTEOPOROSIS, INTERMITTENT
  • İstanbul Üniversitesi Adresli: Evet

Özet

ObjectiveParathyroid hormone (PTH) enhances bone healing. Strontium ranelate (SR) is an antiresorptive agent that increases bone formation. Reports about combined effects of PTH and SR on local bone regeneration in osteoporotic subjects are limited. We aimed at investigating the efficacy of PTH and SR for promoting new bone formation in critical-sized defects of ovariectomized rats.