Combined effect of parathyroid hormone and strontium ranelate on bone healing in ovariectomized rats

GÖKER F., Ersanli S., Arisan V., Cevher E., Guzel E. E., Issever H., ...More

ORAL DISEASES, vol.24, no.7, pp.1255-1269, 2018 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 7
  • Publication Date: 2018
  • Doi Number: 10.1111/odi.12895
  • Journal Name: ORAL DISEASES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1255-1269
  • Keywords: bone healing, chitosan, osteoporosis, ovariectomized rat, parathyroid hormone, strontium ranelate, CHITOSAN NANOPARTICLES, HYDROXYAPATITE COATINGS, POSTMENOPAUSAL WOMEN, SYNTHETIC MATRIX, MINERAL DENSITY, TERIPARATIDE, REGENERATION, ALENDRONATE, OSTEOPOROSIS, INTERMITTENT
  • Istanbul University Affiliated: Yes

Abstract

ObjectiveParathyroid hormone (PTH) enhances bone healing. Strontium ranelate (SR) is an antiresorptive agent that increases bone formation. Reports about combined effects of PTH and SR on local bone regeneration in osteoporotic subjects are limited. We aimed at investigating the efficacy of PTH and SR for promoting new bone formation in critical-sized defects of ovariectomized rats.