Inflammation is associated to volume status in peritoneal dialysis patients

ÜNAL A., KAVUNCUOĞLU F., DURAN M., OĞUZ F., KOÇYİĞİT İ., SİPAHİOĞLU M. H., ...More

RENAL FAILURE, vol.37, no.6, pp.935-940, 2015 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 6
  • Publication Date: 2015
  • Doi Number: 10.3109/0886022x.2015.1040337
  • Journal Name: RENAL FAILURE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.935-940
  • Keywords: Gender, hypervolemia, inflammation, peritoneal dialysis, residual renal function, RESIDUAL RENAL-FUNCTION, BLOOD-PRESSURE, CARDIOVASCULAR-DISEASE, HEMODIALYSIS-PATIENTS, OXIDATIVE STRESS, BODY-COMPOSITION, KIDNEY-DISEASE, MARKERS, SODIUM, WATER
  • Istanbul University Affiliated: No

Abstract

Aim: The aim of this study is to investigate whether there is a relationship between inflammation and volume status in patients underwent peritoneal dialysis (PD). Patients and method: This cross-sectional study included 159 PD patients. The median duration of PD was 17 (range, 1-151) months. All patients were examined using bioelectrical impedance analysis to estimate the ratio of extracellular water to total body water (ECW/TBW), which was used to assess their volume status. The patients were categorized as having one of the following three volume statuses: hypervolemic (above + 2 SD from the mean, which was obtained from healthy controls), normovolemic (between + 2 SD and -2 SD), or hypovolemic (below -2 SD from the mean). Five patients with hypovolemia were excluded from the study. Fifty-six patients were hypervolemic whereas 98 patients were euvolemic. High-sensitive C-reactive protein (hs-CRP) levels were measured to evaluate inflammation in all patients. Results: hs-CRP value levels were significantly higher in hypervolemic patients compared with euvolemic patients [7.1 (3.1-44.0) mg/L vs. 4.3 (3.1-39.6), p: 0.015, respectively]. Left ventricular hypertrophy was more frequent in hypervolemic patients compared with euvolemic patients (53.6% vs. 30.6%, p: 0.004, respectively). ECW/TBW ratio positively correlated with hs-CRP (r: 0.166, p: 0.039). Gender, hs-CRP, and residual Kt/V urea were found to be independent risk factors for hypervolemia in multivariate analysis. Conclusion: Inflammation is associated with hypervolemia in PD patients. Residual renal functions play an important role to maintain euvolemia in PD patients.