Is there any association between apolipoprotein E and angiotensin converting enzyme gene polymorphism in patients with Parkinson's disease and dementia in Turkish Population?

Agachan B. , YILMAZ H. , AYDIN M., ISBIR T.

NEUROSCIENCE RESEARCH COMMUNICATIONS, cilt.27, ss.165-173, 2000 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 27 Konu: 3
  • Basım Tarihi: 2000
  • Sayfa Sayıları: ss.165-173


The genetic factors which predispose individuals to dementia in old age have not been fully defined. The epsilon4 allele of the gene encoding apolipoprotein E (Apo E) is the only well replicated genetic risk factor for non-autosomal dominant forms of Alzheimer's disease (AD). Recent reports indicate that the Angiotensin Converting Enzyme (ACE) Deletion (D) polymorphism is associated with a high risk for coronary heart disease and may effect longevity/survival into old age. Since there is no study concerning polymorphism of the Apo E and ACE gene and dementia subtypes in Turkish population, we have examined the these polymorphism in patients with dementia and Parkinson's disease,