Chitosan:Gene Delivery

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in: Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, Munmaya M., Editor, Taylor & Francis, New York, pp.1735-1749, 2016

  • Publication Type: Book Chapter / Chapter Research Book
  • Publication Date: 2016
  • Publisher: Taylor & Francis
  • City: New York
  • Page Numbers: pp.1735-1749
  • Editors: Munmaya M., Editor
  • Istanbul University Affiliated: Yes


Gene delivery is the most innovative therapeutic method in the field of the molecular

medicine. Viral and non-viral vectors, which are the carrier systems for the gene

transfer, are used for the gene delivery. Since the development and use of the first

non-viral vector, the various synthetic, natural and modified natural cationic polymers

have been used for gene delivery applications and investigated their transfection

efficiency. Chitosan, which is the biodegradable and non-toxic cationic polysaccharide,

are generally preferred than the other cationic polymers as a non-viral vector due to

the mainly its properties of chemical versatility, excellence in transcellular transport,

effective DNA-condensing agent, efficient and permanent transfection. The objective of

this review is to indicate the importance and give an overview of applications of

chitosan and its derivatives as novel non-viral vectors for gene delivery.