Synthesis, antioxidant activities of the nickel(II), iron(III) and oxovanadium(IV) complexes with N2O2 chelating thiosemicarbazones


Bal-Demirci T., Sahin M., Ozyurek M., Kondakci E., Ulkuseven B.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, vol.126, pp.317-323, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 126
  • Publication Date: 2014
  • Doi Number: 10.1016/j.saa.2014.02.039
  • Journal Name: SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.317-323
  • Keywords: Thiosemicarbazone, Nickel, Iron, Vanadium, Antioxidant, RADICAL SCAVENGING ACTIVITY, TRANSITION-METAL-COMPLEXES, RAY CRYSTAL-STRUCTURES, IRON CHELATORS, IN-VITRO, COPPER(II), ASSAY, FLAVONOIDS, PHENOLICS, PROTEIN
  • Istanbul University Affiliated: Yes

Abstract

The nickel(II), iron(III) and oxovanadium(IV) complexes of the N2O2 chelating thiosemicarbazones were synthesized using 4-hydroxysalicyladehyde-S-methylthiosemicarbazone and R-1-substitute-salicylaldehyde (R-1: 4-OH, H) in the presence of Ni(II), Fe(III), VO(IV) ions by the template reaction. The structures of the thiosemicarbazone complexes were characterized by FT-IR, H-1 NMR, elemental, ESI-MS and APCI-MS analysis. The synthesized compounds were screened for their antioxidant capacity by using the cupric reducing antioxidant capacity (CUPRAC) method. Trolox equivalent antioxidant capacity (TEAC) of iron(III) complex, 1c, was measured to be higher than that of the other complexes. Other parameters of antioxidant activity (scavenging effects on OH, O-2(-) and H2O2) of these compounds were also determined. All the compounds have shown encouraging ROS scavenging activities. (c) 2014 Elsevier B.V. All rights reserved.