Synthesis, antioxidant activities of the nickel(II), iron(III) and oxovanadium(IV) complexes with N2O2 chelating thiosemicarbazones

Bal-Demirci T., Sahin M., Ozyurek M., Kondakci E., Ulkuseven B.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, cilt.126, ss.317-323, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 126
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.saa.2014.02.039
  • Dergi Adı: SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.317-323
  • Anahtar Kelimeler: Thiosemicarbazone, Nickel, Iron, Vanadium, Antioxidant, RADICAL SCAVENGING ACTIVITY, TRANSITION-METAL-COMPLEXES, RAY CRYSTAL-STRUCTURES, IRON CHELATORS, IN-VITRO, COPPER(II), ASSAY, FLAVONOIDS, PHENOLICS, PROTEIN
  • İstanbul Üniversitesi Adresli: Evet

Özet

The nickel(II), iron(III) and oxovanadium(IV) complexes of the N2O2 chelating thiosemicarbazones were synthesized using 4-hydroxysalicyladehyde-S-methylthiosemicarbazone and R-1-substitute-salicylaldehyde (R-1: 4-OH, H) in the presence of Ni(II), Fe(III), VO(IV) ions by the template reaction. The structures of the thiosemicarbazone complexes were characterized by FT-IR, H-1 NMR, elemental, ESI-MS and APCI-MS analysis. The synthesized compounds were screened for their antioxidant capacity by using the cupric reducing antioxidant capacity (CUPRAC) method. Trolox equivalent antioxidant capacity (TEAC) of iron(III) complex, 1c, was measured to be higher than that of the other complexes. Other parameters of antioxidant activity (scavenging effects on OH, O-2(-) and H2O2) of these compounds were also determined. All the compounds have shown encouraging ROS scavenging activities. (c) 2014 Elsevier B.V. All rights reserved.