Anti-neuronal and stress-induced-phosphoprotein 1 antibodies in neuro-Behcet's disease

Vural B., Ugurel E., Tuzun E., Kurtuncu M., Zuliani L., Cavus F., ...More

JOURNAL OF NEUROIMMUNOLOGY, no.1-2, pp.91-97, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2011
  • Doi Number: 10.1016/j.jneuroim.2011.08.008
  • Journal Name: JOURNAL OF NEUROIMMUNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.91-97
  • Keywords: Behcet's disease, Neuro-Behcet's disease, Anti-neuronal antibody, Stress-induced-phosphoprotein 1, Antibody, Autoimmunity, HEAT-SHOCK-PROTEIN, LIMBIC ENCEPHALITIS, MULTIPLE-SCLEROSIS, RHEUMATOID-ARTHRITIS, POTASSIUM, IMMUNOREACTIVITY, AUTOANTIBODIES, CRYSTALLIN, CANDIDATE, CRITERIA
  • Istanbul University Affiliated: Yes

Abstract

No disease-specific neuronal antibodies have so far been defined in neuro-Behcet's disease (NBD). Immunohistochemistry and immunocytochemistry studies showed antibodies to hippocampal and cerebellar molecular layers and the surface antigens of cultured hippocampal neurons in sera and/or cerebrospinal fluids (CSF) of 13 of 20 NBD and 6 of 20 BD patients but not in multiple sclerosis or headache controls. Screening with a protein macroarray led to identification of stress-induced-phosphoprotein-1 (STIP-1) as an antigenic target. High-titer STIP-1-antibodies were detected in 6 NBD patients' sera but not in controls. These results suggest that neuronal antibodies could be useful as diagnostic biomarkers in NBD. (C) 2011 Elsevier B.V. All rights reserved.