Anti-neuronal and stress-induced-phosphoprotein 1 antibodies in neuro-Behcet's disease

Vural B., Ugurel E., Tuzun E., Kurtuncu M., Zuliani L., Cavus F., ...Daha Fazla

JOURNAL OF NEUROIMMUNOLOGY, sa.1-2, ss.91-97, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.jneuroim.2011.08.008
  • Dergi Adı: JOURNAL OF NEUROIMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.91-97
  • Anahtar Kelimeler: Behcet's disease, Neuro-Behcet's disease, Anti-neuronal antibody, Stress-induced-phosphoprotein 1, Antibody, Autoimmunity, HEAT-SHOCK-PROTEIN, LIMBIC ENCEPHALITIS, MULTIPLE-SCLEROSIS, RHEUMATOID-ARTHRITIS, POTASSIUM, IMMUNOREACTIVITY, AUTOANTIBODIES, CRYSTALLIN, CANDIDATE, CRITERIA
  • İstanbul Üniversitesi Adresli: Evet

Özet

No disease-specific neuronal antibodies have so far been defined in neuro-Behcet's disease (NBD). Immunohistochemistry and immunocytochemistry studies showed antibodies to hippocampal and cerebellar molecular layers and the surface antigens of cultured hippocampal neurons in sera and/or cerebrospinal fluids (CSF) of 13 of 20 NBD and 6 of 20 BD patients but not in multiple sclerosis or headache controls. Screening with a protein macroarray led to identification of stress-induced-phosphoprotein-1 (STIP-1) as an antigenic target. High-titer STIP-1-antibodies were detected in 6 NBD patients' sera but not in controls. These results suggest that neuronal antibodies could be useful as diagnostic biomarkers in NBD. (C) 2011 Elsevier B.V. All rights reserved.