The effect of fluoxetine on ischemia-reperfusion after aortic surgery in a rat model

Guner I., Yaman M. O., Aksu U., Uzun D., Erman H., Inceli M., ...Daha Fazla

JOURNAL OF SURGICAL RESEARCH, cilt.189, sa.1, ss.96-105, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 189 Sayı: 1
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.jss.2014.02.033
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.96-105
  • Anahtar Kelimeler: Fluoxetine, Lung injury, Abdominal aorta, Ischemia-reperfusion, Reactive oxygen species, Ischemia-modified albumin, MESSENGER-RNA LEVELS, ACUTE LUNG INJURY, OXIDATIVE STRESS, MODIFIED ALBUMIN, ANTIOXIDANT ACTIVITY, BIOMARKERS, ASSAY, ANTIDEPRESSANTS, INHIBITOR, ENZYMES
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: Aortic ischemia-reperfusion (IR) is an important factor in the development of postoperative acute lung injury after abdominal aortic surgery. The aim of the present study was to examine the effect of fluoxetine (Flx), a selective serotonin reuptake inhibitor widely used as a preoperative anxiolytic, on lung injury induced by abdominal aortic IR in rats.