How sesquiterpenes modulate signaling cascades in cancers

Jabeen S., Qureshi M. Z., Attar R., Aslam A., Kanwal S., Khalid S., ...More

CELLULAR AND MOLECULAR BIOLOGY, vol.62, no.7, pp.110-117, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 62 Issue: 7
  • Publication Date: 2016
  • Doi Number: 10.14715/cmb/2016.62.7.19
  • Journal Name: CELLULAR AND MOLECULAR BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.110-117
  • Istanbul University Affiliated: Yes

Abstract

Data obtained from high-throughput technologies has started to shed light on the interplay between signal transduction cascades and chromatin modifications thus adding another layer of complexity to the already complex regulation of the protein network. Based on the insights gleaned from almost a decade of research, it has now been convincingly revealed that sesquiterpenes effectively modulated different intracellular signaling cascades in different cancers. In this review we summarize how sesquiterpenes mediated Wnt, Shh, Notch and TRAIL induced signaling cascades.