Biodistribution and computed tomography studies on iopromide liposomes

Erdogan S., Ozer A., Ercan M., AYDIN K., Hincal A.

STP PHARMA SCIENCES, vol.8, no.2, pp.133-137, 1998 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 2
  • Publication Date: 1998
  • Journal Name: STP PHARMA SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.133-137
  • Keywords: liposomes, iopromide, biodistribution, computed tomography, drug delivery system
  • Istanbul University Affiliated: Yes

Abstract

Liposomes containing iopromide were prepared by film method followed by extrusion. Biodistribution and computed tomography imaging efficiency were evaluated in rats. Liposomes were taken up by the reticulo-endothelial system localized in the macrophages or Kupffer cells. The best biodistribution and computed tomography enhancement of the liver images were obtained with formulation E2 (PL100/SA/Chol 7/2/4 molar ratio, liquid crystalline state).