Biodistribution and computed tomography studies on iopromide liposomes


Erdogan S. , Ozer A., Ercan M., AYDIN K. , Hincal A.

STP PHARMA SCIENCES, vol.8, no.2, pp.133-137, 1998 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 2
  • Publication Date: 1998
  • Journal Name: STP PHARMA SCIENCES
  • Journal Indexes: Science Citation Index Expanded
  • Page Numbers: pp.133-137
  • Keywords: liposomes, iopromide, biodistribution, computed tomography, drug delivery system

Abstract

Liposomes containing iopromide were prepared by film method followed by extrusion. Biodistribution and computed tomography imaging efficiency were evaluated in rats. Liposomes were taken up by the reticulo-endothelial system localized in the macrophages or Kupffer cells. The best biodistribution and computed tomography enhancement of the liver images were obtained with formulation E2 (PL100/SA/Chol 7/2/4 molar ratio, liquid crystalline state).