Biodistribution and computed tomography studies on iopromide liposomes

Erdogan S., Ozer A., Ercan M., AYDIN K., Hincal A.

STP PHARMA SCIENCES, cilt.8, sa.2, ss.133-137, 1998 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 2
  • Basım Tarihi: 1998
  • Dergi Adı: STP PHARMA SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.133-137
  • Anahtar Kelimeler: liposomes, iopromide, biodistribution, computed tomography, drug delivery system
  • İstanbul Üniversitesi Adresli: Evet

Özet

Liposomes containing iopromide were prepared by film method followed by extrusion. Biodistribution and computed tomography imaging efficiency were evaluated in rats. Liposomes were taken up by the reticulo-endothelial system localized in the macrophages or Kupffer cells. The best biodistribution and computed tomography enhancement of the liver images were obtained with formulation E2 (PL100/SA/Chol 7/2/4 molar ratio, liquid crystalline state).