A Role for Heterozygosity of NF-kappa B1 rs28362491 Polymorphism in Patients with Idiopathic Oligospermia


Tek B., Elcin P., Tuncdemir M. , Onaran I. , Ozkara H., Sultuybek G.

ARCHIVES OF IRANIAN MEDICINE, vol.19, no.4, pp.275-281, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 4
  • Publication Date: 2016
  • Journal Name: ARCHIVES OF IRANIAN MEDICINE
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.275-281

Abstract

Background: Nuclear factor-kappa B (NF-kB) activation and its inhibition by NF-kB inhibitor (IkB) have been functionally linked to germ cell apoptosis, which may affect human infertility. We hypothesized a possible relationship between the NF-kappa B1-94insidel ATTG (rs28362491) and NF-kappa BIA 3'UTR A -> G (rs696) polymorphism, which are common polymorphisms and the susceptibility to oligospermia in the context of the sperm apoptosis.