A Role for Heterozygosity of NF-kappa B1 rs28362491 Polymorphism in Patients with Idiopathic Oligospermia


Tek B., Elcin P., Tuncdemir M. , Onaran I. , Ozkara H., Sultuybek G.

ARCHIVES OF IRANIAN MEDICINE, cilt.19, ss.275-281, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 19 Konu: 4
  • Basım Tarihi: 2016
  • Dergi Adı: ARCHIVES OF IRANIAN MEDICINE
  • Sayfa Sayıları: ss.275-281

Özet

Background: Nuclear factor-kappa B (NF-kB) activation and its inhibition by NF-kB inhibitor (IkB) have been functionally linked to germ cell apoptosis, which may affect human infertility. We hypothesized a possible relationship between the NF-kappa B1-94insidel ATTG (rs28362491) and NF-kappa BIA 3'UTR A -> G (rs696) polymorphism, which are common polymorphisms and the susceptibility to oligospermia in the context of the sperm apoptosis.