CD4 costimulation is not required in a novel LPS-enhanced model of myasthenia gravis
JOURNAL OF NEUROIMMUNOLOGY, cilt.249, ss.1-7, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 249
- Basım Tarihi: 2012
- Doi Numarası: 10.1016/j.jneuroim.2012.04.002
- Dergi Adı: JOURNAL OF NEUROIMMUNOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1-7
- Anahtar Kelimeler: Myasthenia gravis, Experimental autoimmune myasthenia gravis, Autoimmunity, Lipopolysaccharide, CD4, ACETYLCHOLINE-RECEPTORS, AUTOIMMUNE-DISEASES, IMMUNE-RESPONSES, T-CELLS, MICE, COMPLEMENT, DIFFERENTIATION, INHIBITION, ANTIBODIES, INDUCTION
- İstanbul Üniversitesi Adresli: Evet
Özet
The potential of lipopolysaccharide (LPS) to induce antigen-specific B cell responses to acetylcholine receptor (AChR) in myasthenia gravis (MG) was evaluated in wild type (WT) and CD4-/- C57BL/6 mice. The WT mice immunized with AChR in LPS developed an MG-like disease (LPS-EAMG) similar to that induced by immunization with AChR in complete Freund's adjuvant (CFA-EAMG). CD4-/- mice were resistant to CFA-EAMG but susceptible to LPS-EAMG. LPS abrogated EAMG resistance in CD4-/- mice by increasing high-affinity anti-AChR IgG2b in sera and enhancing immune complex deposition in muscle. (C) 2012 Elsevier B.V. All rights reserved.