Evaluation of T Lymphocyte Subgroups in Patients with Chronic Lymphocytic Leukemia

GELMEZ M. Y., ÇINAR S., Daglar-Aday A., Gurel G. O., Yonal-Hindilerden I., DENİZ G., ...Daha Fazla

TURKISH JOURNAL OF IMMUNOLOGY, cilt.8, sa.1, ss.6-12, 2020 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.25002/tji.2020.1240
  • Dergi Adı: TURKISH JOURNAL OF IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.6-12
  • Anahtar Kelimeler: Chronic Lymphocytic Leukemia, Follicular T cells, CLL, CELL FUNCTION, EXPRESSION, AID, DISEASE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Introduction: Chronic lymphocytic leukemia (CLL) that arises by malignant transformation of mature B cell is the most common leukemia in elderly. CLL is characterized by accumulation of CD5(+)CD19(+) cells in the peripheral blood and lymphoid organs. While CD8(+) T lymphocytes response intracellular pathogen and tumor, CD4(+) T lymphocytes regulate immune response. T follicular (Tfol) cells stimulate affinity maturation and class-switch recombination in B lymphocytes due to cytokine and surface molecules. In this study, we aimed to investigate CD4(+)T, CD8(+)T and CD3(+)CD4(+)CXCR5(+) follicular T (Tfol) cells in the peripheral blood of the CLL patients compared to healthy controls.