Evaluation of T Lymphocyte Subgroups in Patients with Chronic Lymphocytic Leukemia

GELMEZ M. Y., ÇINAR S., Daglar-Aday A., Gurel G. O., Yonal-Hindilerden I., DENİZ G., ...More

TURKISH JOURNAL OF IMMUNOLOGY, vol.8, no.1, pp.6-12, 2020 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.25002/tji.2020.1240
  • Journal Name: TURKISH JOURNAL OF IMMUNOLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.6-12
  • Keywords: Chronic Lymphocytic Leukemia, Follicular T cells, CLL, CELL FUNCTION, EXPRESSION, AID, DISEASE
  • Istanbul University Affiliated: Yes

Abstract

Introduction: Chronic lymphocytic leukemia (CLL) that arises by malignant transformation of mature B cell is the most common leukemia in elderly. CLL is characterized by accumulation of CD5(+)CD19(+) cells in the peripheral blood and lymphoid organs. While CD8(+) T lymphocytes response intracellular pathogen and tumor, CD4(+) T lymphocytes regulate immune response. T follicular (Tfol) cells stimulate affinity maturation and class-switch recombination in B lymphocytes due to cytokine and surface molecules. In this study, we aimed to investigate CD4(+)T, CD8(+)T and CD3(+)CD4(+)CXCR5(+) follicular T (Tfol) cells in the peripheral blood of the CLL patients compared to healthy controls.