Vitamin E has a dual effect of anti-inflammatory and antioxidant activities in acetic acid-induced ulcerative colitis in rats


Tahan G., Aytac E., Aytekin H., GÜNDÜZ F., Dogusoy G., Aydin S., ...More

CANADIAN JOURNAL OF SURGERY, vol.54, no.5, pp.333-338, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 5
  • Publication Date: 2011
  • Doi Number: 10.1503/cjs.013610
  • Title of Journal : CANADIAN JOURNAL OF SURGERY
  • Page Numbers: pp.333-338

Abstract

Background: Increased free radical production, decreased antioxidant capacity and excessive inflammation are well-known features in the pathogenesis of inflammatory bowel disease. Vitamin E is a powerful antioxidant and a scavenger of hydroxyl radicals, and it has been shown to have anti-inflammatory activities in tissues. We investigated the effects of vitamin E on inflammatory activities using an acetic acid (AA)induced ulcerative colitis model in rats.