Genetic factors associated with the predisposition to late onset Alzheimer's disease


DURMAZ A., Kumral E., Durmaz B., ONAY H., Aslan G. I. , Ozkinay F., ...More

GENE, vol.707, pp.212-215, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 707
  • Publication Date: 2019
  • Doi Number: 10.1016/j.gene.2019.05.030
  • Journal Name: GENE
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.212-215
  • Keywords: Genetic polymorphism, MTHFR, ACE, BDNF, Late-onset Alzheimer's disease, MTHFR C677T POLYMORPHISM, RISK-FACTOR, PLASMA HOMOCYSTEINE, EPSILON-4, DEMENTIA, MEMORY, ROLES, BDNF

Abstract

Background Alzheimer's disease is a progressive, irreversible neurodegenerative disorder characterized by loss of memory and cognitive skills. More than 90% of cases are sporadic and have later age of onset. Many studies have shown a genetic predisposition for late onset Alzheimer's disease (LOAD). The most studied genetic predisposition factor is apolipoprotein E gene besides other susceptibility genes involved in vascular pathologies, homocysteine metabolism, and neuronal growth and differentiation such as methylenetetrahydrofolate reductase (MTHFR), angiotensin-converting enzyme (ACE), APOB and brain derived neurotrophic factor (BDNF).