Genetic factors associated with the predisposition to late onset Alzheimer's disease


DURMAZ A., Kumral E., Durmaz B., ONAY H., Aslan G. I., Ozkinay F., ...Daha Fazla

GENE, cilt.707, ss.212-215, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 707
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.gene.2019.05.030
  • Dergi Adı: GENE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.212-215
  • Anahtar Kelimeler: Genetic polymorphism, MTHFR, ACE, BDNF, Late-onset Alzheimer's disease, MTHFR C677T POLYMORPHISM, RISK-FACTOR, PLASMA HOMOCYSTEINE, EPSILON-4, DEMENTIA, MEMORY, ROLES, BDNF
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background Alzheimer's disease is a progressive, irreversible neurodegenerative disorder characterized by loss of memory and cognitive skills. More than 90% of cases are sporadic and have later age of onset. Many studies have shown a genetic predisposition for late onset Alzheimer's disease (LOAD). The most studied genetic predisposition factor is apolipoprotein E gene besides other susceptibility genes involved in vascular pathologies, homocysteine metabolism, and neuronal growth and differentiation such as methylenetetrahydrofolate reductase (MTHFR), angiotensin-converting enzyme (ACE), APOB and brain derived neurotrophic factor (BDNF).