In Silico Analysis of Potential Vaccine Antigens for the Treatment of Crimean-Congo Hemorrhagic Fever Virus (Cchfv)

Tülümen D., Aydemir E., Ayaz F.

Pharmaceutical Research, cilt.43, sa.3, ss.653-666, 2026 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 3
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1007/s11095-025-04002-2
  • Dergi Adı: Pharmaceutical Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, Chimica, EMBASE, INSPEC, MEDLINE
  • Sayfa Sayıları: ss.653-666
  • Anahtar Kelimeler: crimean-congo hemorrhagic fever virus (CCHFV), hyalomma marginatum, in-silico, vaccine candidates
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: Crimean-Congo hemorrhagic fever virus (CCHFV), identified by the World Health Organization(WHO) as a potential epidemic threat, is a tick-borne Nairovirus primarily transmitted by Hyalomma marginatum species. Since its first detection in the 1940s, CCHFV has spread to multiple regions worldwide and remains a major public health concern due to its high fatality rate and expanding geographic distribution. The virus can be transmitted through tick bites or contact with infected individuals, and no licensed vaccine is currently available to prevent infection. Methods: In this study, two CCHFV proteins, Q8JSZ3 (GP_CCHFI) and Q6TQR6 (L_CCHFI), were retrieved from public databases and analyzed using bioinformatic tools to explore their potential as vaccine candidates. Results: The computational analyses revealed that both proteins possess non-toxic characteristics and show promise for future vaccine design. Conclusions: These findings provide a preliminary in-silico framework that may guide the development of effective vaccines against CCHFV.