Copeptin Does Not Add Diagnostic Information to High-Sensitivity Troponin T in Low- to Intermediate-Risk Patients with Acute Chest Pain: Results from the Rule Out Myocardial Infarction by Computed Tomography (ROMICAT) Study

Creative Commons License

Karakas M., Januzzi J. L. , Meyer J., Lee H., Schlett C. L. , Truong Q. A. , ...More

CLINICAL CHEMISTRY, vol.57, no.8, pp.1137-1145, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 8
  • Publication Date: 2011
  • Doi Number: 10.1373/clinchem.2010.160192
  • Title of Journal : CLINICAL CHEMISTRY
  • Page Numbers: pp.1137-1145


PURPOSE: Copeptin, a stable peptide derived from the AVP precursor, has been linked to presence and severity of myocardial ischemia. We sought to evaluate the predictive value of copeptin and its incremental value beyond that of high-sensitivity cardiac troponin T (hs-cTnT) in patients with acute chest pain and low to intermediate risk for acute coronary syndrome (ACS).