Cytotoxic Sesterterpenoids from Bornean Sponge Spongia sp
RECORDS OF NATURAL PRODUCTS, vol.12, no.6, pp.643-647, 2018 (SCI-Expanded, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 12 Issue: 6
- Publication Date: 2018
- Doi Number: 10.25135/rnp.69.18.01.209
- Journal Name: RECORDS OF NATURAL PRODUCTS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.643-647
- Istanbul University Affiliated: No
Abstract
Four scalarane sesterterpenoids, scalarolide acetate (1), scalarolide (2), 12-O-deacetyl-12-epi-19-O-methylscalarin (3) and methyl 18-hydroxy-19-norscalar-16-en-20-carboxylate (4) were isolated from the Bornean sponge Spongia sp. The distinction between 12 alpha-OAc and 12 beta-OAc, and 19-olide and 20-olide in sesterterpenes were revealed as well as previously not assigned relative configuration at 18-OH of 4 is reported herein for the first time. In addition, compounds 1-3 showed strong cytotoxic activities against adult T-cell leukemia (ATL), SIT cells. This is the first record of scalarane sesterterpenes from the Bornean sponge.