Cytotoxic Sesterterpenoids from Bornean Sponge Spongia sp


Phan C., Kamada T., Hamada T., Vairappan C. S.

RECORDS OF NATURAL PRODUCTS, cilt.12, ss.643-647, 2018 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 12 Konu: 6
  • Basım Tarihi: 2018
  • Doi Numarası: 10.25135/rnp.69.18.01.209
  • Dergi Adı: RECORDS OF NATURAL PRODUCTS
  • Sayfa Sayıları: ss.643-647

Özet

Four scalarane sesterterpenoids, scalarolide acetate (1), scalarolide (2), 12-O-deacetyl-12-epi-19-O-methylscalarin (3) and methyl 18-hydroxy-19-norscalar-16-en-20-carboxylate (4) were isolated from the Bornean sponge Spongia sp. The distinction between 12 alpha-OAc and 12 beta-OAc, and 19-olide and 20-olide in sesterterpenes were revealed as well as previously not assigned relative configuration at 18-OH of 4 is reported herein for the first time. In addition, compounds 1-3 showed strong cytotoxic activities against adult T-cell leukemia (ATL), SIT cells. This is the first record of scalarane sesterterpenes from the Bornean sponge.