Akademik Veri Yönetim Sistemi
Oncology Letters, cilt.31, sa.2, 2026 (SCI-Expanded, Scopus)
Endometrial cancer (EC) is the fourth most common malignancy in women in high‑income countries and the sixth globally, with ~417,000 new cases and ~97,370 mortalities reported worldwide in 2020. Its incidence has increased by >130% over the past 30 years, due to advances in FIGO‑based staging systems and earlier detection. However effective non‑invasive biomarkers for early diagnosis and staging are limited. Non‑coding RNAs (ncRNAs), particu‑ larly long ncRNAs (lncRNAs) and microRNAs (miRs), are critical regulators in the biology of cancer, and may poten‑ tially serve as novel diagnostic and prognostic biomarkers. In the present study, serum levels of the lncRNA Hox antisense intergenic RNA (HOTAIR) and the miR‑646 were evaluated in 71 patients with EC and 62 matched healthy controls using reverse transcription‑quantitative PCR. The results showed that the serum HOTAIR expression level was significantly increased in patients with EC compared with controls. This suggested that it may have potential as a diagnostic biomarker. Although overall miR‑646 levels did not differ significantly between patients with EC and healthy controls, a notable reduction in miR‑646 levels were observed in patients with advanced clinical T stages compared with those with early stages. This indicated an association with disease progression. Receiver operating characteristic curve analyses indicated that a serum HOTAIR level of 1.08 may distinguish patients with EC from healthy controls with 63.3% sensitivity and 61.2% specificity. Additionally, a miR‑646 cut‑off value of 0.655 differentiated patients with advanced‑stage from early‑stage EC with 72.7% sensitivity and 66.7% specificity.