Strategies to manage hepatitis C virus (HCV) disease burden


Wedemeyer H., Duberg A. S. , Buti M., Rosenberg W. M. , Frankova S., Esmat G., ...Daha Fazla

JOURNAL OF VIRAL HEPATITIS, cilt.21, ss.60-89, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 21
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1111/jvh.12249
  • Dergi Adı: JOURNAL OF VIRAL HEPATITIS
  • Sayfa Sayıları: ss.60-89

Özet

The number of hepatitis C virus (HCV) infections is projected to decline while those with advanced liver disease will increase. A modeling approach was used to forecast two treatment scenarios: (i) the impact of increased treatment efficacy while keeping the number of treated patients constant and (ii) increasing efficacy and treatment rate. This analysis suggests that successful diagnosis and treatment of a small proportion of patients can contribute significantly to the reduction of disease burden in the countries studied. The largest reduction in HCV-related morbidity and mortality occurs when increased treatment is combined with higher efficacy therapies, generally in combination with increased diagnosis. With a treatment rate of approximately 10%, this analysis suggests it is possible to achieve elimination of HCV (defined as a >90% decline in total infections by 2030). However, for most countries presented, this will require a 3-5 fold increase in diagnosis and/or treatment. Thus, building the public health and clinical provider capacity for improved diagnosis and treatment will be critical.