Antimalarial agents from plants - II. Decursivine, a new antimalarial indole alkaloid from Rhaphidophora decursiva

Zhang H., Qiu S., Tamez P., Tan G., Aydogmus Z., Van Hung N., ...More

PHARMACEUTICAL BIOLOGY, vol.40, no.3, pp.221-224, 2002 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 3
  • Publication Date: 2002
  • Doi Number: 10.1076/phbi.40.3.221.5832
  • Journal Name: PHARMACEUTICAL BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.221-224
  • Keywords: Rhaphidophora decursiva, Araceae, decursivine, indole alkaloid, 2D NMR, bioassay-directed fractionation, antimalarial activity
  • Istanbul University Affiliated: Yes

Abstract

Antimalarial bioassay-directed fractionation led to the isolation of a new active indole alkaloid, decursivine (1), from the leaves and stems of Rhaphidophora decursiva Schott (Araceae). In addition, a leaf sample yielded the structurally-related compound serotobenine (2), previously reported from a taxonomically unrelated family, which was not active against Plasmodium falciparum. The structure of 1 was elucidated by spectroscopic means, and its antimalarial activity was observed with IC50 values of 3.93 and 4.41 mug/ml against the D6 and W2 clones of Plasmodium falciparum, respectively.