Spectrophotometric determination of 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors in pharmaceutical preparations

Ergin G., Caglar S., Onal A., Erturk Toker S.

TURKISH JOURNAL OF CHEMISTRY, cilt.37, sa.2, ss.171-181, 2013 (SCI-Expanded)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3906/kim-1106-58
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.171-181
  • Anahtar Kelimeler: HMG-CoA reductase inhibitors, spectrophotometric determination, charge-transfer reaction, TCNQ, pharmaceutical preparations, PERFORMANCE LIQUID-CHROMATOGRAPHY, CHARGE-TRANSFER COMPLEXATION, SPIKED HUMAN PLASMA, ROSUVASTATIN CALCIUM, QUANTITATIVE-DETERMINATION, MOLECULAR-COMPLEXES, DOSAGE FORMS, PI-ACCEPTORS, PURE FORM, BULK DRUG
  • İstanbul Üniversitesi Adresli: Evet

Özet

Simple and accurate spectrophotometric methods are presented for the determination of five 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors (statins), namely atorvastatin, fluvastatin, pitavastatin, rosuvastatin, and simvastatin, in pharmaceutical preparations. The methods are based on the reaction of drugs as n-electron donor with 7,7,8,8-tetracyanoquinodimethane as pi-acceptors to give highly colored complex species. All variables were studied in order to optimize the reaction conditions. Beer's law was obeyed in the concentration ranges 4-20 mu g mL(-1), 4-12 mu g mL(-1), 0.8-2.4 mu g mL(-1), 4-14 mu g mL(-1), and 2.5-20 mu g mL(-1) for atorvastatin, fluvastatin, pitavastatin, rosuvastatin, and simvastatin, respectively. The proposed methods were successfully applied to the pharmaceutical preparations without any interference from excipients.
Spectrophotometric determination of 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors in pharmaceutical preparations
Author(s): Ergin, G (Ergin, Gamze)[ 1 ] ; Caglar, S (Caglar, Sena)[ 1 ] ; Onal, A (Onal, Armagan)[ 1 ] ; Erturk Toker, S(Erturk Toker, Sidika)[ 1 ]
Source: TURKISH JOURNAL OF CHEMISTRY  Volume: 37   Issue: 2   Pages: 171-181   DOI: 10.3906/kim-1106-58  Published: 2013
Times Cited: 0 (from Web of Science)
Cited References: 47      [ view related records ]     Citation MapCitation Map     
Abstract: Simple and accurate spectrophotometric methods are presented for the determination of five 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors (statins), namely atorvastatin, fluvastatin, pitavastatin, rosuvastatin, and simvastatin, in pharmaceutical preparations. The methods are based on the reaction of drugs as n-electron donor with 7,7,8,8-tetracyanoquinodimethane as pi-acceptors to give highly colored complex species. All variables were studied in order to optimize the reaction conditions. Beer's law was obeyed in the concentration ranges 4-20 mu g mL(-1), 4-12 mu g mL(-1), 0.8-2.4 mu g mL(-1), 4-14 mu g mL(-1), and 2.5-20 mu g mL(-1) for atorvastatin, fluvastatin, pitavastatin, rosuvastatin, and simvastatin, respectively. The proposed methods were successfully applied to the pharmaceutical preparations without any interference from excipients.
Accession Number: WOS:000317819800001