FARMACO, cilt.50, sa.3, ss.189-192, 1995 (SCI-Expanded)
Several 1,1-bis(4-alkyl/aryl-1,2,4-triazoline-5-thione-3-yl)-2-methylbutane derivatives 13-21 were obtained from the cyclization of mono(1-methylpropyl)malonylbis(4-alkyl/aryl)thiosemicarbazides 2-12 in the presence of sodium hydroxide. Their chemical structures were proven by spectral data (UV, IR, H-1-NMR, MS) and elemental analysis. The anticonvulsant activity of the title compounds were determined against pentylenetetrazole induced seizures. Six of the tested compounds showed anticonvulsant activity (10 to 20% protection).