SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME NEW 1,1-BIS(4-SUBSTITUTED 1,2,4-TRIAZOLINE-5-THIONE-3-YL)2-METHYLBUTANES


ERGENC N., ULUSOY N., EKINCI A.

FARMACO, vol.50, no.3, pp.189-192, 1995 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 3
  • Publication Date: 1995
  • Title of Journal : FARMACO
  • Page Numbers: pp.189-192

Abstract

Several 1,1-bis(4-alkyl/aryl-1,2,4-triazoline-5-thione-3-yl)-2-methylbutane derivatives 13-21 were obtained from the cyclization of mono(1-methylpropyl)malonylbis(4-alkyl/aryl)thiosemicarbazides 2-12 in the presence of sodium hydroxide. Their chemical structures were proven by spectral data (UV, IR, H-1-NMR, MS) and elemental analysis. The anticonvulsant activity of the title compounds were determined against pentylenetetrazole induced seizures. Six of the tested compounds showed anticonvulsant activity (10 to 20% protection).