Relationship of CTLA4 and CD28 polymorphisms with lung involvement, HRCT findings and pulmonary function tests in Turkish patients with ankylosing spondylitis

OKYALTIRIK F., Rezvani A., Turan S., UYSAL Ö., Yakar F. , Sozgen H., ...Daha Fazla

CLINICAL RESPIRATORY JOURNAL, cilt.11, ss.593-601, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 11 Konu: 5
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1111/crj.12388
  • Sayfa Sayıları: ss.593-601


Background and AimsAnkylosing spondylitis (AS) is a multisystem disorder with ocular, pulmonary, and cardiovascular involvement. The incidence of pulmonary involvement varies from 1 to 52%. Abnormal T-cell function-derived immune responses are involved in AS pathogenesis. Numerous genes such as CTLA4 and CD28 control T-cell functions. In this study, we aimed to address the relationship between CTLA4 and CD28 polymorphisms and lung involvement in Turkish patients with AS.