Relationship of CTLA4 and CD28 polymorphisms with lung involvement, HRCT findings and pulmonary function tests in Turkish patients with ankylosing spondylitis


OKYALTIRIK F., Rezvani A., Turan S., UYSAL Ö., Yakar F. , Sozgen H., ...More

CLINICAL RESPIRATORY JOURNAL, vol.11, no.5, pp.593-601, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 5
  • Publication Date: 2017
  • Doi Number: 10.1111/crj.12388
  • Journal Name: CLINICAL RESPIRATORY JOURNAL
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.593-601
  • Keywords: Ankylosing spondylitis, CD28, CTLA4, lung involvement, QUALITY-OF-LIFE, GENE POLYMORPHISMS, COMPUTED-TOMOGRAPHY, DISEASE, MANIFESTATIONS, ASSOCIATION

Abstract

Background and AimsAnkylosing spondylitis (AS) is a multisystem disorder with ocular, pulmonary, and cardiovascular involvement. The incidence of pulmonary involvement varies from 1 to 52%. Abnormal T-cell function-derived immune responses are involved in AS pathogenesis. Numerous genes such as CTLA4 and CD28 control T-cell functions. In this study, we aimed to address the relationship between CTLA4 and CD28 polymorphisms and lung involvement in Turkish patients with AS.