Akademik Veri Yönetim Sistemi
BioTürkiye Uluslararası Biyoteknoloji Kongresi, İstanbul, Türkiye, 5 - 07 Mart 2020, cilt.1, sa.1, ss.57, (Özet Bildiri)
Increasing multidrug-resistance to pathogens, particularly to Staphylococci, Enterococci and Streptococci, is a major problem, resulting in significant morbidity, mortality and healthcare costs. In recent years, only a small number of effective
novel antibiotics against Gram-positive bacteria has been approved. Searching of novel antibiotics has gained importance to overcome this issue threating human being.
In this study we have identified a non-pathogenic bacterium belonging Serratia fonticola strain using whole shot gun genome sequence analysis and has been labelled as “AGBY19”. Genome analyses of AGBY19 revealed that the bacteria harbours different gene clusters comprising flanked regions associated with the production of secondary metabolites providing antibiotic properties against bacteria. 30 genes associated with production of bacteriocins and proteases in studied genome with their detection e-values and products was determined. These genes might be used for recombinant DNA technology to produce new antibiotics and enhance the efficacious of known existing antibiotics in pharmacology.
Therefore, our strain has remarkable importance as alternative and effective antibiotic producer and further studies are required to understand of its inhibitory effect on different pathogens.