A comparison of clinical findings of familial Mediterranean fever patients with and without amyloidosis

CEFLE A., KAMALI S., SAYARLIOGLU M., Inanc M., Ocal L., Aral O., ...Daha Fazla

RHEUMATOLOGY INTERNATIONAL, cilt.25, sa.6, ss.442-446, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 6
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1007/s00296-004-0471-z
  • Dergi Adı: RHEUMATOLOGY INTERNATIONAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.442-446
  • Anahtar Kelimeler: amyloidosis, chronic renal failure, familial Mediterranean fever, PHENOTYPE-GENOTYPE CORRELATION, MEFV, MUTATION, COLCHICINE, PROGNOSIS, FMF
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: This study investigates the clinical and demographic characteristics of familial Mediterranean fever (FMF) patients with and without amyloidosis. Patients and methods: The clinical data of 503 patients with FMF (females: males 250: 253) were reviewed. Fifty of these patients had amyloidosis (f:m 23: 27). Results: The ages of attack onset in patients with and without amyloidosis were 7.8 +/- 6.2 and 11.1 +/- 8.5, respectively (P < 0.05). The time between disease onset and diagnosis was longer in patients with amyloidosis than those without (187.6 +/- 99.4 months and 132.5 +/- 110.2 months, respectively, P < 0.001). More patients in the amyloidosis group had positive family histories of FMF (68% vs 54%, P < 0.05). The frequencies of chest pain (78% vs 51%, P < 0.001), arthritis (80% vs 60%, P < 0.01), and erysipelas-like erythema (44% vs 16%, P < 0.001) were higher in the amyloidosis group. Conclusion: In the amyloidosis group, FMF-related manifestations of chest pain, arthritis, and erysipelas-like erythema are more frequent. Our results also support that long periods between disease onset and diagnosis are associated with a high risk of developing amyloidosis.